Postdoctoral researcher positions focused on the use of advanced AI techniques such as reinforcement learning and large language models for complex system optimi-zation

80%-100%, fixed-term

Our Sinergia consortium unites expertise at the University of Zurich (Mathematical Modeling & Machine Learning) and ETH Zurich (Department of Mathematics) to push the frontier of data‑driven decision support in large‑scale, real‑world systems under SNSF project “From Single‑Disease Research to Informed Machine Learning. We develop methods that combine reinforcement learning (RL) and large language models (LLMs) to optimize processes, automate design choices and reason about constraints under uncertainty. We will appoint up to two post‑doctoral researchers, each specializing in one of the complementary tracks below. The precise application domain will be defined in consultation with the successful candidates and our research partners in epidemiology and related fields.

Job description

Track A – RL / Optimization

  • Design, implement and evaluate RL frameworks for complex, high‑dimensional environments, leveraging simulation‑based optimization and digital‑twin testbeds
  • Explore multi‑agent or distributed training techniques to scale optimization across interacting subsystems
  • Collaborate with domain scientists to translate algorithms into prototype decision‑support tools

 

Track B – LLM / Knowledge‑Engineering

  • Develop and fine‑tune LLM pipelines that integrate structured reasoning tools (e.g. retrieval‑augmented generation, knowledge graphs, constraint parsers)
  • Build workflows for transparent explanation and evaluation of model decisions
  • Maintain and contribute to open‑source libraries that support reproducible research in the project

 

Both tracks will co‑supervise doctoral students, publish in leading venues, and contribute to open‑source tooling.

Profile

Must have (both tracks)

  • PhD (or equivalent) in computer science, applied mathematics, operations research, physics, statistics or a related field
  • Documented, hands‑on track record of applying RL and/or LLMs to real‑world problems (publications, deployed systems, or open‑source artefacts)
  • Excellent Python skills and familiarity with modern ML stacks (e.g. PyTorch, JAX, Hugging Face)
  • Ability to thrive in an interdisciplinary environment and to communicate complex ideas clearly
  • Prior experience in healthcare, epidemiology, or medical applications of machine learning or statistics (e.g., causal inference) is not required

 

Nice to‑have – Track A

  • Experience with simulation‑based optimization or digital‑twin frameworks
  • Familiarity with multi‑agent RL or distributed training

 

Nice to have – Track B

  • Experience integrating LLMs with structured reasoning tools (RAG, KGs, constraint solvers)
  • Track record of open‑source contributions to RL, LLM or optimization libraries

Workplace

Workplace




We offer

  • Fully funded positions (SNSF postdoctoral scale, approx. CHF 100k/year) within a vibrant, international research environment
  • Mentoring by Nicola Serra (Mathematical Modeling & ML, UZH) and Alessio Figalli (Mathematics, ETHZ), together with the broader Sinergia team
  • Close collaboration with partners in medicine, economics and computer science
  • State‑of‑the‑art computing resources, a generous travel & training budget, and support for industry or clinical secondments
  • A dynamic, family‑friendly workplace in Zurich with competitive Swiss salaries and an excellent quality of life

Curious? So are we.

We look forward to receiving your application with the following documents as a single PDF:

 

  • A cover letter indicating which track you are applying for (RL/Optimization, LLM/Knowledge or both)
  • CV
  • Publication list
  • Contact details of two refereesPlease send your application to [nicola.serra+sinergia@uzh.ch].

 

Further information about [Department of Mathematical Modeling and Machine Learning or Department of Mathematics] can be found on our website: [https://dm3l.uzh.ch or https://math.ethz.ch]. For further information, please contact (Prof. Nicola Serra or Prof. Alessio Figalli) by e-mail (nicola.serra@uzh.ch or figalli@math.ethz.ch) (no application documents).

Applications are reviewed on a rolling basis until the positions are filled. The preferred start date is autumn 2025 (flexible). Applications before September 15, 2025 will be fully considered.