Postdoctoral position in Stem Cell Biology of Skeletal Muscle

100%, Zurich, temporary

A postdoctoral fellow position is available in the Laboratory of Regenerative and Movement Biology at the Department of Health Sciences and Technology (D-HEST).

Project background

The primary scientific interest and direction of the lab is to study the regenerative and therapeutic potential of stem cells, with emphasis on pluripotent and skeletal muscle cells. Specifically, our group is dedicated to developing stem cell-based therapeutic approaches to treat muscle-associated diseases. To this end, we previously devised a method to reprogram mouse fibroblasts into “induced myogenic progenitor cells” by transient expression of the myogenic transcription factor MyoD in concert with three small molecules. These progenitors can propagate extensively in vitro, and repair disease-afflicted muscles in vivo upon engraftment.

Job description

The proposed position will explore means to reprogram human somatic cells directly into functional myogenic progenitors as well as maintain in vitro the stemness properties of muscle stem cells isolated directly from muscles. The work will involve extensive use of molecular biology and tissue culture techniques including: transcription factors and CRISPR-Cas9 library screens, generation of induced pluripotent stem cells carrying genetic reporters, high-throughput screening of small molecules and in vivo muscle stem cell transplantation assays.

Your profile

Interested applicants should have a PhD degree in Biology, Biotechnology, Genetics, Biochemistry, or an equivalent research related field in addition to a strong background in molecular biology assays. Ideally, these will include experience with mammalian cell culture techniques, gene delivery by retro or lenti-viruses, PCR, qPCR, immunostaining, Western blot and FACS analysis. Experience in stem cell or skeletal muscle biology is preferred. Prospective candidates will be part of an international research team and expected to be highly motivated, passionate about science, and collaborative.

ETH Zurich

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.
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Interested?

We look forward to receiving your online application with the following documents: CV, cover letter and names of at least two references. Please note that we exclusively accept applications submitted through our online application portal. Application review will begin on January 31st 2020 and continue until the position is filled.

Further information about the Department of Health Sciences and Technology can be found at: www.hest.ethz.ch. For additional information about the Regenerative and Movement Biology group, please visit our website at: www.rmb.ethz.ch. For questions about the position, please contact Mrs. Marina Molinari-Olejniczak, email: marina-molinari@ethz.ch (please do not send applications directly to this email).

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