PhD student position in fluid dynamics and optics for biomedical applications

This project is a collaboration between the Multiphase Fluid Dynamics group (Prof. Supponen) at the Institute of Fluid Dynamics, and the Functional and Molecular Imaging group (Prof. Razansky) at the Institute of Biomedical Engineering at ETH Zurich.

The research in the newly established Multiphase Fluid Dynamics group at ETH Zurich examines both fundamental and applied questions in various small-scale multiphase fluid phenomena, such as bubble and droplet dynamics and the resulting fast flows. One of our key objectives is to control bubble oscillations to exploit their energy-focusing characteristics in biomedical applications. We also develop experimental techniques to observe and characterise high-speed multiphase fluid phenomena optically and acoustically. The group is part of the Institute of Fluid Dynamics, which pursues a broad range of experimental, numerical and theoretical research efforts in a friendly and inclusive environment with state-of-the-art infrastructure.

The blood-brain barrier (BBB) is a critical protective shield for the brain, but it also poses a major challenge for delivering life-saving drugs to treat neurological diseases like Alzheimer’s disease and brain tumors. Current methods, such as focused ultrasound with microbubbles, are limited in precision and efficiency, often delivering less than 1% of the drug to the brain. To address this, our project introduces a new approach using laser-induced bubble generation to achieve precise, controlled BBB opening (BBBO) for targeted drug delivery. 

Our key objective is to develop a non-invasive, laser-based technique that safely and effectively opens the BBB at energy levels that avoid tissue damage. By generating and controlling highly dynamic vapor bubble activity with laser light, we aim to create temporary openings in the BBB, allowing therapeutic agents to reach the brain with unprecedented precision. By enabling targeted drug delivery, our approach could dramatically improve therapeutic outcomes while minimizing side effects. Unlike existing methods, our technique aims to use laser energies that are safe for biological tissues, ensuring both efficacy and safety.

To achieve these goals, two PhD projects have been designed. One of them will focus on biosafety and in-vivo imaging aspects of the project, and will be hosted by the Functional and Molecular Imaging Group (Prof. Razansky). The second PhD student (this position), hosted by the Multiphase Fluid Dyamics group (Prof. Supponen) has a focus on modelling and high-speed imaging to optimize bubble generation and control, and the resulting particle dynamics and interaction with cells using in-vitro models. We will also validate BBBO in preclinical models, building upon advanced imaging technologies, including fluorescence and optoacoustic imaging, to assess efficacy and optimize the process. The expected output of the project is a novel, laser-based platform for precise BBBO that can be readily translated into clinical applications. This project will not only advance our understanding of BBB permeability but also open new avenues for treating neurological disorders. By focusing on core tasks and leveraging our recent collaborative findings, we aim to deliver impactful results that pave the way for safer, more effective brain therapies.

For more information on our prior research relevant to this project, see:

• Laser-induced bubble dynamics in photoacoustic imaging: Nozdrukhin et al., Small, 2024
• Microbubble dynamics causing sonoporation in endothelial cells: Cattaneo et al., Nature Physics, 2025

• Your job with impact: Become part of ETH Zurich, which not only supports your professional development, but also actively contributes to positive change in society
• We are actively committed to a sustainable and climate-neutral university
• You can expect numerous benefits, such as public transport season tickets and car sharing, a wide range of sports offered by the ASVZ, childcare and attractive pension benefits